You're a How many "out" pitches you have determines how many times through the lineup you should go.

Closers have 1 pitch. Starters have several.

deGrom is one that is a perfect example of this. First time through the order is a heavy dose of his four seamer. Second time through the order he mixes in the two seamer and sprinkles the change. Third time through the order he throws the breaking shit.