The most common side effect is going to be swelling and weight gain. Not good for folks who have heart failure. I don't really like prescribing them honestly. I tend to stay away from prescribing sulfonylureas and TZDs.

Unfortunately, a lot of insurance companies will only pay for them because they are generic and cheap and make you pay more for the better meds like the DPP4s, SGLT2s, and GLP1s.