Originally Posted by
Johnson85
Everyone has the infection that turns them into a zombie, but there is still the infection that comes from a bite. If the infection is from a bite, it's probably already too late for amputation. People don't rot locally from the site of the bite, they get fever and die. He would have had to amputate his hand pretty quickly to ensure that his circulation didn't carry infection. If it's just a general local infection, they have antibiotics at the community. Unless they don't make it back, it should be treatable.
My guess is still that it's from the machete sticking out of the walker and that part of the storyline will be him wondering whether he is infected or not.